BioScience Dictionary

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Found Beta thalassemia 2 times.

Displaying results 1 to 10.

1. Beta thalassemia
This form of thalassemia is due to point mutation s, further subdivided according to pathogenesis: * beta thalassemia major: in this form of beta thalassemia, patients are homozygous for the defective genes: beta0, homozygous beta+, both are life-threatening. * beta thalassemia minor: patients are heterozygous for the defective gene; they have a mild anemia .

2. Beta thalassemia (Cooley's anemia)
One of two major types of thalassemia , a genetically inherited disease, where one of the two types of polypeptide s making up the hemoglobin protein is defective or missing. Hemoglobin proteins are composed of four polypeptides -- two "alpha chains" and two "beta chains". In beta thalassemia, the beta chains are defective or missing (see also alpha thalassemia ). The three classifications of beta thalassemia, in order of increasing severity, are thalassemia minor, thalassemia intermedia, and thalassemia major. Thalassemia major is also known as Cooley's anemia. Symptoms include slow growth, jaundice , enlarged heart, liver, and spleen , thinned bones. Untreated children die young, usually of heart failure or infections. Thalassemia intermedia produces milder symptoms for the first two decades of life in most cases. Thalassemia minor may not produce any symptoms, though changes in the blood occur.