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Denature 2
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| 1. Denature To induce structural alterations that disrupt the biological activity of a molecule. Often refers to breaking hydrogen bond s between base pairs in double-stranded nucleic acid molecules to produce in single-stranded polynucleotides or altering the secondary and tertiary structure of a protein , destroying its activity.
| 2. Denatured protein A protein that, because of heat or detergent application, has lost its native conformation .
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