BioScience Dictionary

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Found Human lymphocyte histocompatibility antigens 1 time.

Displaying results 1 to 10.

1. Human lymphocyte histocompatibility antigens (HLA, HL-A)
Human lymphocyte histocompatibility antigen s were first detected as surface antigens ( glycoprotein s) on peripheral blood lymphocyte s. Later, the HLA regions which codes for the antigens were localized to chromosome 6. Because the HLA complex is inherited intact as two haplotypes (one from each parent), siblings have 1 in 4 chance of being HLA-identical. HLA antigens are of clinically significance because these antigens elicit the strongest immunologic response, therefore, it is responsible for rejection of transplanted tissue and graft versu host reactions. It is also the cause of hemolytic diseases of newborn, erythroblastosis fetalis , kernicterus , and tranfustion reactions with poorly matched or mismatched blood. Furthermore, a host of clinical disorders are associated with HLA is various degrees, e.g. ankylosing spondylitis is associated with HLA B27.