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Found Kernicterus 3 times.

Displaying results 1 to 10.

1. Dystonia
Dystonia the condition of sustained contractions or spasms of muscles of the shoulders, neck, and trunk. It frequently causes twisting and repetitive movements or abnormal postures. Often this is due to disease involving the basal ganglia of the brain which could be related to perinatal anoxia, birth trauma, and kernicterus.

2. Human lymphocyte histocompatibility antigens (HLA, HL-A)
Human lymphocyte histocompatibility antigen s were first detected as surface antigens ( glycoprotein s) on peripheral blood lymphocyte s. Later, the HLA regions which codes for the antigens were localized to chromosome 6. Because the HLA complex is inherited intact as two haplotypes (one from each parent), siblings have 1 in 4 chance of being HLA-identical. HLA antigens are of clinically significance because these antigens elicit the strongest immunologic response, therefore, it is responsible for rejection of transplanted tissue and graft versu host reactions. It is also the cause of hemolytic diseases of newborn, erythroblastosis fetalis , kernicterus , and tranfustion reactions with poorly matched or mismatched blood. Furthermore, a host of clinical disorders are associated with HLA is various degrees, e.g. ankylosing spondylitis is associated with HLA B27.

3. Kernicterus
kernicterus is a clinical syndrome afflicting newborns which is caused by high levels of unconjugated bilirubin which passes the immature blood-brain barrier of the newborn and causes degeneration of cells of the basal ganglia and hippocampus. An affected child displays a range of neurologic disorders: hypertonia , seizure, and cerebral palsy. In severe cases, death is likely.

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