BioScience Dictionary

 
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Found Leukemia 17 times.

Displaying results 1 to 10.

1. 6-mercaptopurine
A toxic drug used to treat acute forms of leukemia (lymphocitic and granulocytic) by inhibiting DNA synthesis.

2. Amethopterin (amethopterine, methotrexate)
A drug which inhibits the proliferation of cancer cells. It is used mainly to treak leukemia , but is also used to suppress the immune systems of transplant patients and to treat psoriasis .

3. Auxin (Agent Orange)
One of several hormone s that plays a role in many aspects of plant growth and development. Auxins include indoleacetic acid, phenylacetic acid, and 4-chloro-indoleacetic acid. Commercially, auxins are used to promote root growth, to promote uniform flowering, and to set fruit and prevent premature fruit drop. Synthetic auxins such as 2,4-D and 2,4,5-T have been used as herbicide s; broad-leaved weeds like dandelions are much more susceptible to auxins than narrow-leaved plants like grass and cereal crops. The defoliant Agent Orange was a mix of 2,4-D and 2,4,5-T. 2,4-D is still in use and is thought to be safe, but 2,4,5-T was more or less banned by the EPA in 1979. The dioxin TCDD is an unavoidable contaminant produced in the manufacture of 2,4,5-T; as a result of the the integral dioxin contamination, 2,4,5-T has been implicated in leukemia , miscarriages, birth defects, liver damage, and other diseases.

4. Cyclophosphamide
A cytotoxin in the nitrogen mustard family which is used both as a chemotherapy agent ( Hodgkin's disease , lymphosarcoma , lymphocytic leukemia , ovarian cancer, etc.) and as an immune system suppressor to prevent transplant rejections.

5. Ets oncogene
A proto- cancer gene which causes leukemia s (blood cancers) in chickens. It is carried and spread by the avian leukemia virus E26 (v-ets). The normal role of the oncogene is the making of a nuclear protein which can bind DNA and which may help activate and proliferate T lymphocyte cells.

6. Human T-cell leukemia virus
One of a group of retrovirus es which causes the disease T-cell leukemia in humans. T-cell leukemia is a type of the cancer leukemia where the body uncontrollably produces large amounts of abnormal (nonworking) T lymphocyte s.

7. Human T-lymphotropic virus type I (HTLV-I)
A human, single-stranded RNA retrovirus from the subfamily Oncovirinae which causes adult T-cell leukemia and T-cell lymphoma and may also be involved in certain demyelinating diseases (diseases where the protective myelin sheath around nerve fibers are destroyed). HTLV-I is closely related to HTLV-II (60% of their genome s are identical).

8. Human T-lymphotropic virus type II (HTLV-II)
A human, single-stranded RNA retrovirus from the subfamily Oncovirinae which may cause diseases such as T-cell leukemia and T-cell lymphoma (but this has not been proven). HTLV-II is closely related to HTLV I (60% of their genome s are identical).

9. Interferon alpha
The main type of interferon (a glycoprotein ) produced by the white blood cell s. It is also manufactured pharmacologically to treat hairy-cell leukemia .

10. K-RAS
A proto- oncogene that has point mutation s and is associated with melanoma, thyroid carcinoma , and acute myelogenous and lymphoblastic leukemia .


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