HOXD3

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HOXD3
Identifiers
AliasesHOXD3, HOX1D, HOX4, HOX4A, Hox-4.1, homeobox D3
External IDsOMIM: 142980 MGI: 96207 HomoloGene: 5034 GeneCards: HOXD3
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for HOXD3
Genomic location for HOXD3
Band2q31.1Start176,136,612 bp[1]
End176,173,102 bp[1]
RNA expression pattern
PBB GE HOXD3 217076 s at fs.png

PBB GE HOXD3 206602 s at fs.png

PBB GE HOXD3 206601 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006898

NM_010468

RefSeq (protein)

NP_008829

NP_034598

Location (UCSC)Chr 2: 176.14 – 176.17 MbChr 2: 74.71 – 74.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.[5][6][7]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128652 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079277 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  7. ^ a b "Entrez Gene: HOXD3 homeobox D3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.