ZEB1

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ZEB1
Protein ZEB1 PDB 2e19.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDsOMIM: 189909 MGI: 1344313 HomoloGene: 31779 GeneCards: ZEB1
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ZEB1
Genomic location for ZEB1
Band10p11.22Start31,318,495 bp[1]
End31,529,814 bp[1]
RNA expression pattern
PBB GE ZEB1 210875 s at fs.png

PBB GE ZEB1 212758 s at fs.png

PBB GE ZEB1 212764 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011546
NM_001360981
NM_001360982

RefSeq (protein)

NP_035676
NP_001347910
NP_001347911

Location (UCSC)Chr 10: 31.32 – 31.53 MbChr 18: 5.59 – 5.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[5][6][7]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[7][8] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[9] The structure of the homeodomain shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148516 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024238 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
  6. ^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  7. ^ a b "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
  8. ^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  9. ^ Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.
  10. ^ Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

Further reading

External links