2-Aminotetralin

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2-Aminotetralin
Systematic (IUPAC) name
1,2,3,4-tetrahydronaphthalen-2-amine
Clinical data
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 2954-50-9
ATC code None
PubChem CID 34677
ChemSpider 31912 YesY
ChEMBL CHEMBL30294 YesY
Chemical data
Formula C10H13N 
Mol. mass 147.217 g/mol
 YesY (what is this?)  (verify)

2-Aminotetralin (2-AT), also known as 1,2,3,4-tetrahydronaphthalen-2-amine (THN), is a stimulant drug with a chemical structure consisting of a tetralin group combined with an amine.12

2-AT is a rigid analogue of phenylisobutylamine and fully substitutes for d-amphetamine in rat discrimination tests, although at one eighth the potency.1 It has been shown to inhibit the reuptake of serotonin and norepinephrine, and likely induces their release as well.34 It is also likely to act on dopamine on account of its full substitution of d-amphetamine in rodent studies.1

Chemical derivatives

A number of derivatives of 2-aminotetralin exist, including:

See also

References

  1. ^ a b c Oberlender R, Nichols DE. (1991). "Structural variation and (+)-amphetamine-like discriminative stimulus properties.". Pharmacol Biochem Behav. 38 (3): 581–586. doi:10.1016/0091-3057(91)90017-V. PMID 2068194. 
  2. ^ Marley E, Stephenson JD (August 1971). "Actions of dexamphetamine and amphetamine-like amines in chickens with brain transections". British Journal of Pharmacology 42 (4): 522–42. PMC 1665761. PMID 5116035. 
  3. ^ Bruinvels J (June 1971). "Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brain". British Journal of Pharmacology 42 (2): 281–6. PMC 1667157. PMID 5091160. 
  4. ^ Bruinvels J, Kemper GC (September 1971). "Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat". British Journal of Pharmacology 43 (1): 1–9. PMC 1665934. PMID 4257629.