ATP8B3

ATPase, aminophospholipid transporter, class I, type 8B, member 3
Identifiers
Symbols	ATP8B3; ATPIK
External IDs	OMIM: 605866 HomoloGene: 19034 GeneCards: ATP8B3 Gene
EC number	3.6.3.1
Gene Ontology Molecular function • magnesium ion binding • phospholipid-translocating ATPase activity • ATP binding • ATPase activity • cation-transporting ATPase activity Cellular component • acrosomal vesicle • integral to membrane Biological process • ATP catabolic process • binding of sperm to zona pellucida • phospholipid translocation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	148229	67331
Ensembl	ENSG00000130270	ENSMUSG00000003341
UniProt	O60423	Q0VF52
RefSeq (mRNA)	NM_001178002	NM_026094
RefSeq (protein)	NP_001171473	NP_080370
Location (UCSC)	Chr 19: 1.78 – 1.81 Mb	Chr 10: 80.52 – 80.54 Mb
PubMed search	[1]	[2]

ATPase, aminophospholipid transporter, class I, type 8B, member 3 is a protein that in humans is encoded by the ATP8B3 gene.

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Further reading

• Halleck, M. S.; Lawler Jf, J. R.; Blackshaw, S.; Gao, L.; Nagarajan, P.; Hacker, C.; Pyle, S.; Newman, J. T. et al. (1999). "Differential expression of putative transbilayer amphipath transporters". Physiological genomics 1 (3): 139–150. PMID 11015572. 
• Harris, M. J.; Arias, I. M. (2003). "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body". Biochimica et Biophysica Acta 1633 (2): 127–131. doi:10.1016/S1388-1981(03)00107-0. PMID 12880872. 
• Fries, A. S.; Svendsen, O. (1978). "Studies on Tyzzer's disease in rats". Laboratory animals 12 (1): 1–4. PMID 146761. 
• Scott, L. J.; Muglia, P.; Kong, X. Q.; Guan, W.; Flickinger, M.; Upmanyu, R.; Tozzi, F.; Li, J. Z. et al. (2009). "Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry". Proceedings of the National Academy of Sciences 106 (18): 7501–7506. doi:10.1073/pnas.0813386106. PMC 2678639. PMID 19416921. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.