Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6gene.123
The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. As of April 2009, an additional function of BMP6 has been identified as described in Nature Genetics April; 41 :386-8. BMP6 is the key regulator of hepcidin, the small peptide secreted by the liver which is the major regulator of iron metabolism in mammals.
^Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Dec 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID1427904.
^Sauermann U, Meyermann R, Schluesener HJ (Jan 1993). "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines". J Neurosci Res33 (1): 142–7. doi:10.1002/jnr.490330118. PMID1453478.
Schluesener HJ, Meyermann R (1995). "Immunolocalization of BMP-6, a novel TGF-beta-related cytokine, in normal and atherosclerotic smooth muscle cells". Atherosclerosis113 (2): 153–6. doi:10.1016/0021-9150(94)05438-O. PMID7605353.
Barnes J, Anthony CT, Wall N, Steiner MS (1997). "Bone morphogenetic protein-6 expression in normal and malignant prostate". World Journal of Urology13 (6): 337–43. PMID9116752.
Hamdy FC, Autzen P, Robinson MC et al. (1997). "Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue". Cancer Res.57 (19): 4427–31. PMID9331107.
Tamada H, Kitazawa R, Gohji K et al. (1998). "Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6)". Biochim. Biophys. Acta1395 (3): 247–51. doi:10.1016/S0167-4781(97)00191-7. PMID9512655.
Ebisawa T, Tada K, Kitajima I et al. (2000). "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation". J. Cell. Sci.112 (20): 3519–27. PMID10504300.
Heikinheimo KA, Laine MA, Ritvos OV et al. (1999). "Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland". Cancer Res.59 (22): 5815–21. PMID10582704.
Ahmed N, Sammons J, Carson RJ et al. (2001). "Effect of bone morphogenetic protein-6 on haemopoietic stem cells and cytokine production in normal human bone marrow stroma". Cell Biol. Int.25 (5): 429–35. doi:10.1006/cbir.2000.0662. PMID11401330.
Shimizu M, Higuchi K, Kasai S et al. (2003). "A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density". Mamm. Genome13 (7): 335–40. doi:10.1007/s00335-001-2129-4. PMID12140680.
Bobacz K, Gruber R, Soleiman A et al. (2003). "Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro". Arthritis Rheum.48 (9): 2501–8. doi:10.1002/art.11248. PMID13130469.
Lories RJ, Derese I, Ceuppens JL, Luyten FP (2003). "Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis". Arthritis Rheum.48 (10): 2807–18. doi:10.1002/art.11389. PMID14558086.
Laurikkala J, Kassai Y, Pakkasjärvi L et al. (2004). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Dev. Biol.264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID14623234.