Bone morphogenetic protein 6

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Bone morphogenetic protein 6
Protein BMP6 PDB 2QCW.png
Rendering based on PDB 2QCW.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BMP6 ; VGR; VGR1
External IDs OMIM112266 MGI88182 HomoloGene1300 GeneCards: BMP6 Gene
RNA expression pattern
PBB GE BMP6 206176 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 654 12161
Ensembl ENSG00000153162 ENSMUSG00000039004
UniProt P22004 P20722
RefSeq (mRNA) NM_001718 NM_007556
RefSeq (protein) NP_001709 NP_031582
Location (UCSC) Chr 6:
7.73 – 7.88 Mb
Chr 13:
38.35 – 38.5 Mb
PubMed search [1] [2]

Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene.123

The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. As of April 2009, an additional function of BMP6 has been identified as described in Nature Genetics April; 41 [4]:386-8. BMP6 is the key regulator of hepcidin, the small peptide secreted by the liver which is the major regulator of iron metabolism in mammals.


3

References

  1. ^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Dec 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904. 
  2. ^ Sauermann U, Meyermann R, Schluesener HJ (Jan 1993). "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines". J Neurosci Res 33 (1): 142–7. doi:10.1002/jnr.490330118. PMID 1453478. 
  3. ^ a b "Entrez Gene: BMP6 bone morphogenetic protein 6". 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.