CEBPE

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CCAAT/enhancer binding protein (C/EBP), epsilon
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CEBPE ; C/EBP-epsilon; CRP1
External IDs OMIM600749 MGI103572 HomoloGene1367 GeneCards: CEBPE Gene
RNA expression pattern
PBB GE CEBPE 214523 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1053 110794
Ensembl ENSG00000092067 ENSMUSG00000052435
UniProt Q15744 Q6PZD9
RefSeq (mRNA) NM_001805 NM_207131
RefSeq (protein) NP_001796 NP_997014
Location (UCSC) Chr 14:
23.59 – 23.59 Mb
Chr 14:
54.71 – 54.71 Mb
PubMed search [1] [2]

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene12 and is pro-apoptotic.3

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.1

References

  1. ^ a b "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon". 
  2. ^ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (July 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101. 
  3. ^ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". J. Biol. Chem. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.