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Suggest pagesD-Deprenyl
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| (2S)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 4528-51-2  |
| ATC code | ? |
| PubChem | CID 199605 |
| ChemSpider | 172774 |
| Chemical data | |
| Formula | C13H17N |
| Mol. mass | 187.28 g/mol |
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D-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor, as well as prodrug to D-amphetamine and D-methamphetamine, and therefore a norepinephrine-dopamine releasing agent. It is the opposite enantiomer of L-deprenyl (selegiline). It was discovered by Wander AG in the 1960s.1
L-Deprenyl, also an MAO-B inhibitor, metabolizes to L-amphetamine and l-methamphetamine, which are selective norepinephrine releasing agents. In contrast, D-deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas L-deprenyl is the opposite.2
See also
- Selegiline (L-Deprenyl)
References
- ^ CH Patent 393306 - Verfahren zur Herstellung von tertiären Aminen der Phenylalkylreihe
- ^ Yasar S, Gaál J, Panlilio LV et al. (January 2006). "A comparison of drug-seeking behavior maintained by d-amphetamine, l-deprenyl (selegiline) and d-deprenyl under a second-order schedule in squirrel monkeys". Psychopharmacology 183 (4): 413–21. doi:10.1007/s00213-005-0200-7. PMC 1360227. PMID 16292593.
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