July 30, 1947 |
|Known for||Discovering HIV|
|Notable awards||2008 Nobel Prize in Physiology or Medicine|
Françoise Barré-Sinoussi (born 30 July 1947) is a French virologist and director of the Regulation of Retroviral Infections Division (Unité de Régulation des Infections Rétrovirales) at the Institut Pasteur in Paris, France. Born in Paris, France, Barré-Sinoussi performed some of the fundamental work in the identification of the human immunodeficiency virus (HIV) as the cause of AIDS. In 2008, she was awarded the Nobel Prize in Physiology or Medicine, together with her former mentor, Luc Montagnier, for their discovery of HIV.1
Barré-Sinoussi joined the Pasteur Institute in Paris in the early 1970s. She received her PhD in 1975 and interned at the U.S. National Institutes of Health before returning to the Pasteur Institute. Barré-Sinoussi's research quickly turned to a particular group of viruses, the retroviruses. Her knowledge in this field led her to discover HIV in 1983. This discovery revealed an urgent need for diagnostic tests to aid in controlling the spread of the disease. Barré-Sinoussi started her own laboratory at the Pasteur Institute in 1988.
Among Barré-Sinoussi's many recent research contributions are studies of various aspects of the adaptive immune response to viral infection,23 the role of innate immune defences of the host in controlling HIV/AIDS,4 factors involved in mother-to-child transmission of HIV,5 and characteristics that allow a small percentage of HIV-positive individuals, known as elite suppressors or controllers, to limit HIV replication without antiretroviral drugs.67 She has co-authored over 240 scientific publications, has participated in over 250 international conferences, and has trained many young researchers.
Barré-Sinoussi has actively contributed to several scientific societies and committees at the Institut Pasteur as well as to other AIDS organizations, such as the National Agency for AIDS Research in France. She has also been implicated at an international level, notably as a consultant to the WHO and the UNAIDS-HIV.
Since the 1980s, Barré-Sinoussi has initiated collaborations with developing countries whereby she has managed multidisciplinary networks with dedication. She constantly works on establishing permanent links between basic research and clinical research with the aim of achieving concrete improvements in the areas of prevention, clinical care, and treatment.8
In July, 2012, Barré-Sinoussi became President of the International AIDS Society.
Barré-Sinoussi shared the 2008 Nobel Prize in Physiology or Medicine with Luc Montagnier for their co-discovery of HIV, and with Harald zur Hausen, who discovered the viral cause of cervical cancer that led to the development of the HPV vaccine.
In addition to the Nobel Prize, Barré-Sinoussi has received awards including:
- the Sovac Prize
- the Körber Foundation Prize for the Promotion of European Science
- the Prize of the French Academy of Sciences (Académie des sciences)
- the King Faisal International Prize
- the International AIDS Society Prize.10
Barré-Sinoussi has been Grand Officer in the National Order of the Legion of Honour (Ordre national de la Légion d’honneur) since 2013.
She received an honorary Doctor of Science degree from Tulane University in May 2009.
- news.bbc.co.uk, Nobel prize for viral discoveries
- Petitjean, G. L.; Chevalier, M. F.; Tibaoui, F.; Didier, C. L.; Manea, M. E.; Liovat, A. S.; Campa, P.; Müller-Trutwin, M. et al. (2012). "Level of double negative T cells, which produce TGF-β and IL-10, predicts CD8 T-cell activation in primary HIV-1 infection". AIDS 26 (2): 139–148. doi:10.1097/QAD.0b013e32834e1484. PMID 22045342.
- Delobel, P.; Nugeyre, M. -T.; Cazabat, M.; Sandres-Saune, K.; Pasquier, C.; Cuzin, L.; Marchou, B.; Massip, P. et al. (2006). "Naive T-Cell Depletion Related to Infection by X4 Human Immunodeficiency Virus Type 1 in Poor Immunological Responders to Highly Active Antiretroviral Therapy". Journal of Virology 80 (20): 10229–10236. doi:10.1128/JVI.00965-06. PMC 1617280. PMID 17005700.
- Liovat, A. S.; Jacquelin, B.; Ploquin, M. J.; Barré-Sinoussi, F.; Müller-Trutwin, M. C. (2009). "African non human primates infected by SIV - why don't they get sick? Lessons from studies on the early phase of non-pathogenic SIV infection". Current HIV research 7 (1): 39–50. PMID 19149553.
- Marlin, R.; Nugeyre, M. T. R. S.; Duriez, M.; Cannou, C.; Le Breton, A.; Berkane, N.; Barré-Sinoussi, F. O.; Menu, E. (2011). "Decidual soluble factors participate in the control of HIV-1 infection at the maternofetal interface". Retrovirology 8: 58. doi:10.1186/1742-4690-8-58. PMC 3156730. PMID 21767373.
- Saez-Cirion, A.; Hamimi, C.; Bergamaschi, A.; David, A.; Versmisse, P.; Melard, A.; Boufassa, F.; Barre-Sinoussi, F. et al. (2011). "Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers". Blood 118 (4): 955–964. doi:10.1182/blood-2010-12-327106. PMC 3148172. PMID 21642597.
- Saez-Cirion, A.; Sinet, M.; Shin, S. Y.; Urrutia, A.; Versmisse, P.; Lacabaratz, C.; Boufassa, F.; Avettand-Fenoel, V. et al. (2009). "Heterogeneity in HIV Suppression by CD8 T Cells from HIV Controllers: Association with Gag-Specific CD8 T Cell Responses". The Journal of Immunology 182 (12): 7828–7837. doi:10.4049/jimmunol.0803928. PMID 19494307.
- WITI Hall of Fame
- Lettre ouverte à Benoît XVI
- Asia Leadership Center, Biography
|Wikimedia Commons has media related to: Françoise Barré-Sinoussi|
- PROFILE: Luc Montagnier, Francoise Barre-Sinoussi - AIDS pioneers
- Barre-Sinoussi Nobel Prize lecture
- Institut Pasteur – Unité de Régulation des Infections Rétrovirales
- Abstract of paper describing the discovery of HIV
- Press release from the Karolinska Institutet
- Article: "Nobel prize winner that identified HIV says cure is feasible"