GFI1

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Growth factor independent 1 transcription repressor
Identifiers
Symbols GFI1 ; GFI-1; GFI1A; SCN2; ZNF163
External IDs OMIM600871 MGI103170 HomoloGene3854 GeneCards: GFI1 Gene
RNA expression pattern
PBB GE GFI1 206589 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2672 14581
Ensembl ENSG00000162676 ENSMUSG00000029275
UniProt Q99684 P70338
RefSeq (mRNA) NM_001127215 NM_001267621
RefSeq (protein) NP_001120687 NP_001254550
Location (UCSC) Chr 1:
92.94 – 92.95 Mb
Chr 5:
107.72 – 107.73 Mb
PubMed search [1] [2]

Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.12


Interactions

GFI1 has been shown to interact with PIAS33 and RUNX1T1.4

References

  1. ^ Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidler-McKay P, Grimes HL, Tsichlis PN, Testa JR (July 1995). "Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents". Cytogenet Cell Genet 70 (3–4): 263–7. doi:10.1159/000134048. PMID 7789186. 
  2. ^ "Entrez Gene: GFI1 growth factor independent 1". 
  3. ^ Rödel, B; Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer H P, Möröy T (November 2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. (ENGLAND) 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. ISSN 0261-4189. PMC 305799. PMID 11060035. 
  4. ^ McGhee, Laura; Bryan Josh, Elliott Liza, Grimes H Leighton, Kazanjian Avedis, Davis J Nathan, Meyers Shari (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. (United States) 89 (5): 1005–18. doi:10.1002/jcb.10548. ISSN 0730-2312. PMID 12874834. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.