Homeobox A10

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Homeobox A10
Identifiers
Symbols HOXA10 ; HOX1; HOX1.8; HOX1H; PL
External IDs OMIM142957 MGI96171 HomoloGene7365 GeneCards: HOXA10 Gene
RNA expression pattern
PBB GE HOXA10 213150 at tn.png
PBB GE HOXA10 213147 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3206 15395
Ensembl ENSG00000253293 ENSMUSG00000000938
UniProt P31260 P31310
RefSeq (mRNA) NM_018951 NM_001122950
RefSeq (protein) NP_061824 NP_001116422
Location (UCSC) Chr 7:
27.21 – 27.22 Mb
Chr 6:
52.23 – 52.24 Mb
PubMed search [1] [2]

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.123

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.3

Interactions

Homeobox A10 has been shown to interact with PTPN6.4

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXA10 homeobox A10". 
  4. ^ Eklund, Elizabeth A; Goldenberg Inna, Lu YuFeng, Andrejic Jelena, Kakar Renu (Sep 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". J. Biol. Chem. (United States) 277 (39): 36878–88. doi:10.1074/jbc.M203917200. ISSN 0021-9258. PMID 12145285. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.