Liver receptor homolog-1

Nuclear receptor subfamily 5, group A, member 2
	; PDB rendering based on 1yok.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1YOK, 1YUC, 1ZDU, 2A66, 3PLZ, 3TX7, 4DOR, 4DOS, 4IS8
Identifiers
Symbols	NR5A2; B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; LRH1; hB1F-2
External IDs	OMIM: 604453 MGI: 1346834 HomoloGene: 20827 IUPHAR: NR5A2 ChEMBL: 3544 GeneCards: NR5A2 Gene
Gene Ontology
Molecular function	• DNA binding; • double-stranded DNA binding; • sequence-specific DNA binding transcription factor activity; • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; • steroid hormone receptor activity; • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; • protein binding; • phospholipid binding; • zinc ion binding; • sequence-specific DNA binding; • transcription regulatory region DNA binding;
Cellular component	• nucleus; • nucleoplasm; • cytoplasm;
Biological process	• regulation of transcription, DNA-dependent; • transcription initiation from RNA polymerase II promoter; • bile acid metabolic process; • embryo development; • gene expression; • endocrine pancreas development; • regulation of cell proliferation; • homeostatic process; • cholesterol homeostasis; • positive regulation of viral genome replication; • positive regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter;
	Sources: Amigo / QuickGO
Orthologs
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The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.¹² LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.³⁴⁵

LRH-1 is important for maintaining pluripotence of stem cells during embryonic development.⁶

Interactions

Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.⁷⁸

References

^ Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Mol. Cell. Biol. 13 (3): 1619–33. PMC 359474. PMID 7680097.
^ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833.
^ Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends Cell Biol. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.
^ Luo, Y.; Liang, C. P.; Tall, A. R. (2001). "The Orphan Nuclear Receptor LRH-1 Potentiates the Sterol-mediated Induction of the Human CETP Gene by Liver X Receptor". Journal of Biological Chemistry 276 (27): 24767–24773. doi:10.1074/jbc.M100912200. PMID 11331284.
^ Nitta, M. (1999). "CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha -hydroxylase gene". Proceedings of the National Academy of Sciences 96 (12): 6660–6665. doi:10.1073/pnas.96.12.6660.
^ Gu, P.; Goodwin, B.; Chung, A. C. -K.; Xu, X.; Wheeler, D. A.; Price, R. R.; Galardi, C.; Peng, L. et al. (2005). "Orphan Nuclear Receptor LRH-1 is Required to Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development". Molecular and Cellular Biology 25 (9): 3492–3505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC 1084298. PMID 15831456. |displayauthors= suggested (help)
^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.
^ Lee YK, Moore DD (January 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.

External links

NR5A2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[pmid7680097-1] Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Mol. Cell. Biol. 13 (3): 1619–33. PMC 359474. PMID 7680097.

[pmid9858833-2] Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833.

[pmid15130581-3] Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends Cell Biol. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.

[CETP-4] Luo, Y.; Liang, C. P.; Tall, A. R. (2001). "The Orphan Nuclear Receptor LRH-1 Potentiates the Sterol-mediated Induction of the Human CETP Gene by Liver X Receptor". Journal of Biological Chemistry 276 (27): 24767–24773. doi:10.1074/jbc.M100912200. PMID 11331284.

[cholesterolhydroxylase-5] Nitta, M. (1999). "CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha -hydroxylase gene". Proceedings of the National Academy of Sciences 96 (12): 6660–6665. doi:10.1073/pnas.96.12.6660.

[6] Gu, P.; Goodwin, B.; Chung, A. C. -K.; Xu, X.; Wheeler, D. A.; Price, R. R.; Galardi, C.; Peng, L. et al. (2005). "Orphan Nuclear Receptor LRH-1 is Required to Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development". Molecular and Cellular Biology 25 (9): 3492–3505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC 1084298. PMID 15831456. |displayauthors= suggested (help)

[pmid12198243-7] Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.

[pmid11668176-8] Lee YK, Moore DD (January 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.

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Liver receptor homolog-1

Contents

Interactions

References

Further reading

External links