Mitogen-activated protein kinase kinase kinase 12 is an enzyme that in humans is encoded by the MAP3K12gene.12
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.2
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Robitaille H, Proulx R, Robitaille K, et al. (2005). "The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation.". J. Biol. Chem.280 (13): 12732–41. doi:10.1074/jbc.M411619200. PMID15695824.