MLX (gene)

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MLX, MAX dimerization protein
Symbols MLX ; MAD7; MXD7; TCFL4; bHLHd13
External IDs OMIM602976 MGI108398 HomoloGene7969 GeneCards: MLX Gene
RNA expression pattern
PBB GE MLX 213708 s at tn.png
PBB GE MLX 210752 s at tn.png
PBB GE MLX 217909 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6945 21428
Ensembl ENSG00000108788 ENSMUSG00000017801
UniProt Q9UH92 O08609
RefSeq (mRNA) NM_170607 NM_001159384
RefSeq (protein) NP_733752 NP_001152856
Location (UCSC) Chr 17:
42.57 – 42.57 Mb
Chr 11:
101.09 – 101.09 Mb
PubMed search [1] [2]

Max-like protein X is a protein that in humans is encoded by the MLX gene.12

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.2


MLX (gene) has been shown to interact with MNT,34 MXD134 and MLXIPL.3


  1. ^ Bjerknes M, Cheng H (January 1997). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301. 
  2. ^ a b "Entrez Gene: MLX MAX-like protein X". 
  3. ^ a b c Cairo, S; Merla G; Urbinati F; Ballabio A; Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. (England) 10 (6): 617–27. doi:10.1093/hmg/10.6.617. ISSN 0964-6906. PMID 11230181. 
  4. ^ a b Meroni, G; Cairo S; Merla G; Messali S; Brent R; Ballabio A; Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene (ENGLAND) 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.