Morazone

Morazone
Systematic (IUPAC) name
	1,5-dimethyl-4-[(3-methyl-2-phenylmorpholin-4-yl)methyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
Clinical data
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral, SC, IM
Identifiers
CAS number	6536-18-1
ATC code	None
PubChem	CID 39609
ChemSpider	36216
UNII	870Q5BL2FN
Chemical data
Formula	C23H27N3O2
Mol. mass	377.48 g/mol
	SMILES O=C1\C(=C(/N(N1c2ccccc2)C)C)CN3C(C(OCC3)c4ccccc4)C;
	InChI InChI=1S/C23H27N3O2/c1-17-21(23(27)26(24(17)3)20-12-8-5-9-13-20)16-25-14-15-28-22(18(25)2)19-10-6-4-7-11-19/h4-13,18,22H,14-16H2,1-3H3 ; Key:OOGNFQMTGRZRAB-UHFFFAOYSA-N ;
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Morazone (Novartrina, Orsimon, Rosimon-Neu, Tarcuzate) is a non-steroidal anti-inflammatory drug (NSAID) originally developed by the German pharmaceutical company Ravensberg in the 1950s which is used as an analgesic.¹²³ It produces phenmetrazine as a major metabolite and has been reported to have been abused as a recreational drug in the past.⁴⁵⁶⁷

References

^ ^a ^b Seyffart, G. (1991). Drug dosage in renal insufficiency. Boston: Kluwer Academic Publishers. p. 399. ISBN 0-7923-0964-2.
^ US patent 2943022, Siemer, H. & Doppstadt, A., "Substituted l-phenyl-2,3-dimethyl-4-morpholino methyl pyrazolone-(S) Compounds and Process of making same", issued 1960-06-28, assigned to Ravensberg
^ Dictionary of organic compounds. London: Chapman & Hall. 1996. p. 4659. ISBN 0-412-54090-8.
^ Bohn, G.; Rücker, G.; Kröger, H. (1976). "Investigations of the decomposition and detection of morazone by thin-layer- and gas-liquid-chromatography". Archives of toxicology 35 (3): 213–220. PMID 989292.
^ Neugebauer, M. (1984). "Some new urinary metabolites of famprofazone and morazone in man". Journal of pharmaceutical and biomedical analysis 2 (1): 53–60. PMID 16867765.
^ Kingreen, J. C.; Breger, G. (1984). "Pellagra in morazone abuse". Zeitschrift für Hautkrankheiten 59 (9): 573–577. PMID 6145264.
^ Daunderer, M.; Janzen, W. (1972). "Rosimon-NEU--a non-prescription analgesic on the adolescent drug scene". Beiträge zur gerichtlichen Medizin 29: 138–143. PMID 5081964.