Robert Edwards (physiologist)
|Sir Robert Edwards|
|Born||Robert Geoffrey Edwards
27 September 19251
|Died||10 April 2013
|Fields||Physiology and reproductive medicine|
|Institutions||University of Cambridge
University of Edinburgh
National Institute for Medical Research
University of Glasgow
California Institute of Technology
Churchill College, Cambridge
|Alma mater||Bangor University
University of Edinburgh
|Thesis||The experimental induction of heteroploidy in the mouse (1955)|
|Known for||Pioneer of in-vitro fertilisation|
|Notable awards||Nobel Prize in Physiology or Medicine (2010)|
|Spouse||Ruth Fowler Edwards1|
Sir Robert Geoffrey Edwards, CBE, FRS23 (27 September 1925 – 10 April 2013) was a British physiologist and pioneer in reproductive medicine and in-vitro fertilisation (IVF) in particular. Along with surgeon Patrick Steptoe,4 Edwards successfully pioneered conception through IVF, which led to the birth of the first test-tube baby,5 Louise Brown, on 25 July 1978.67 This was achieved with the drug Pergonal which was already used for ovarian follicular stimulation in infertile women. It was developed by Serono,8 the global biotechnology business built by three generations of the Bertarelli family.9 He was awarded the 2010 Nobel Prize in Physiology or Medicine "for the development of in vitro fertilization".10
Edwards was born in Batley, Yorkshire.11 After finishing Manchester Central High School1 on Whitworth Street in central Manchester, he served in the British Army, and then completed his undergraduate studies in biology at the Bangor University.1213 He studied at the Institute of Animal Genetics and Embryology at Edinburgh University, where he was awarded a PhD in 1955.14 After a year as a research fellow at the California Institute of Technology he joined the scientific staff of the National Institute for Medical Research at Mill Hill. After a further year at the University of Glasgow, in 1963 he moved to the University of Cambridge as Ford Foundation Research Fellow at the Department of Physiology, and a member of Churchill College, Cambridge. He was appointed Reader in physiology in 1969.15
Circa 1960 Edwards started to study human fertilisation, and he continued his work at Cambridge, laying the groundwork for his later success. In 1968 he was able to achieve fertilisation of a human egg in the laboratory and started to collaborate with Patrick Steptoe, a gynecologic surgeon from Oldham. Edwards developed human culture media to allow the fertilisation and early embryo culture, while Steptoe utilized laparoscopy to recover ovocytes from patients with tubal infertility. Their attempts met significant hostility and opposition,16 including a refusal of the Medical Research Council to fund their research and a number of lawsuits.17 Additional historical information on this controversial era in the development of IVF has been published.18
The birth of Louise Brown, the world's first 'test-tube baby', at 11:47 pm on 25 July 1978 at the Oldham General Hospital made medical history: in vitro fertilisation meant a new way to help infertile couples who formerly had no possibility of having a baby.
Refinements in technology have increased pregnancy rates and it is estimated that in 2010 about 4 million children have been born by IVF,10 with approximately 170,000 coming from donated oocyte and embryos.192021 Their breakthrough laid the groundwork for further innovations such as intracytoplasmatic sperm injection ICSI, embryo biopsy (PGD), and stem cell research.
Edwards and Steptoe founded the Bourn Hall Clinic as a place to advance their work and train new specialists. Steptoe died in 1988. Edwards continued on in his career as a scientist and an editor of medical journals.
- In 1984, Edwards was elected as a Fellow of the Royal Society.2
- In 1994, Doctor Honoris Causa, University of Valencia (Spain).
- In 2001, he was awarded the Albert Lasker Clinical Medical Research Award by the Lasker Foundation "for the development of in vitro fertilization, a technological advance that has revolutionized the treatment of human infertility."22
- In 2007, he was ranked 26th in The Daily Telegraph's list of 100 greatest living geniuses.23
- In 2007, he was awarded an honorary doctorate from the University of Huddersfield.
- On 4 October 2010, it was announced that Edwards had been awarded the 2010 Nobel Prize in Physiology or Medicine for the development of in-vitro fertilization.10 The Nobel Committee praised him for advancing treatment of infertility and noted that IVF babies have similar health statuses to ordinary babies.24 Göran K. Hansson, secretary of the Nobel Assembly at the Karolinska Institutet in Stockholm, announced the news.24 The first child of IVF Louise Brown described the award as "fantastic news".25 A Vatican official condemned the move as "completely out of order".2526
- Edwards was knighted in the 2011 Birthday Honours for services to human reproductive biology.2728
Edwards died on 10 April 2013 after a long lung illness.30 A spokesperson for the University of Cambridge said "He will be greatly missed by family, friends and colleagues."31 The Guardian reported that, as of Edwards' death, more than four million births had resulted from IVF.31 Louise Brown said "His work, along with Patrick Steptoe, has brought happiness and joy to millions of people all over the world by enabling them to have children."32 According to the BBC, his work was motivated by his belief that "the most important thing in life is having a child."32
- "EDWARDS, Sir Robert (Geoffrey)". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press.(subscription required)
- Johnson, M. H. (2011). "Robert Edwards: The path to IVF". Reproductive BioMedicine Online 23 (2): 245–262. doi:10.1016/j.rbmo.2011.04.010. PMC 3171154. PMID 21680248.
- Fisher, S. J.; Giudice, L. C. (2013). "Robert G. Edwards (1925-2013)". Science 340 (6134): 825. doi:10.1126/science.1239644. PMID 23687039.
- Edwards, R. G. (1996). "Patrick Christopher Steptoe, C. B. E. 9 June 1913-22 March 1988". Biographical Memoirs of Fellows of the Royal Society 42: 434–426. doi:10.1098/rsbm.1996.0027.
- Steptoe, P. C.; Edwards, R. G. (1978). "Birth After the Reimplantation of a Human Embryo". The Lancet 312 (8085): 366. doi:10.1016/S0140-6736(78)92957-4. PMID 79723.
- "1978: First 'test tube baby' born". BBC. 1978-07-25. Retrieved 2009-06-13. "The birth of the world's first "test tube baby" has been announced in Manchester (England). Louise Brown was born shortly before midnight in Oldham and District General Hospital"
- Moreton, Cole (2007-01-14). "World's first test-tube baby Louise Brown has a child of her own". London: Independent. Retrieved 2010-05-22. "The 28-year-old, whose pioneering conception by in-vitro fertilisation made her famous around the world ... The fertility specialists Patrick Steptoe and Bob Edwards became the first to successfully carry out IVF by extracting an egg, impregnating it with sperm and planting the resulting embryo back into the mother."
- http://www.waypointcapital.net/history History of Bertarelli involvement with Serono]
- "The 2010 Nobel Prize in Physiology or Medicine – Press Release". Nobelprize.org. 2010-10-04. Retrieved 2010-10-04.
- Kolata, Gina (10 April 2013). "Robert G. Edwards Dies at 87; Changed Rules of Conception With First ‘Test Tube Baby’". The New York Times. Retrieved 13 April 2013.
- "SLA Biomedical & Life Sciences Division Blog: Robert G. Edwards : 2010 Nobel Prize Winner in Physiology or Medicine". Sla-divisions.typepad.com. 2010-10-07. Retrieved 2013-04-14.
- "Health Zone 24x7 - Health - Fitness - Medicine - Medical". Healthzone24x7.blogspot.com. Retrieved 2013-04-14.
- Edwards, Robert Geoffrey (1955). The Experimental Induction of Heteroploidy in the Mouse (PhD thesis). University of Edinburgh. http://books.google.co.uk/books?id=-8ggcgAACAAJ.
- 6:23PM BST 10 Apr 2013 (2013-04-10). "Professor Sir Robert Edwards". Telegraph. Retrieved 2013-04-14.
- Myers, PZ (2010-10-04). "A surprising Nobel". Retrieved 2010-10-04.
- Wade, Nicholas (October 4, 2010). "Pioneer of in Vitro Fertilization Wins Nobel Prize". New York Times. Retrieved October 5, 2010.
- Joseph D. Schulman, M.D., 2010. "Robert G. Edwards – A Personal Viewpoint"
- "Home — OBG Management". Obgmanagement.com. Retrieved 2013-04-14.
- "Library". TheAFA.org. Retrieved 2013-04-14.
- "Lasker Award for Clinical Medical Research 2001". Laskerfoundation.org. 2007-09-16. Retrieved 2010-10-04.
- "Top 100 living geniuses". The Daily Telegraph (London). 2007-10-28. Retrieved 2010-10-04.
- "Nobel in medicine for IVF pioneer". The Times of India. 2010-10-05. Retrieved 2010-10-05.
- "Vatican official criticises Nobel win for IVF pioneer". BBC News. 2010-10-04. Retrieved 2010-10-04.
- "Vatican slams Nobel win for IVF doc". The Sydney Morning Herald. 2010-10-05. Retrieved 2010-10-05.
- The London Gazette: . 11 June 2011.
- "Queen's birthday honours list: Knights". London: The Guardian. 2011-06-11. Retrieved 11 June 2011.
- "Index entry". FreeBMD. ONS. Retrieved 12 April 2013.
- "IVF pioneer dies". Cambridge News. Retrieved 10 April 2013.
- Jones, Sam (10 April 2013). "IVF pioneer Robert Edwards dies aged 87". The Guardian. Retrieved 10 April 2013.
- "Test-tube baby pioneer Sir Robert Edwards dies". BBC News. 10 April 2013. Retrieved 10 April 2013.