Ronald Duman

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Ronald S. Duman is a Professor of Psychiatry and Pharmacology Director, Division of Molecular Psychiatry and Abraham Ribicoff Research Facilities at Yale University.[1]


Duman received his Ph.D. in 1985 from The University of Texas Health Science Center at Houston.


Ron Duman's research centers around the biological mechanisms behind antidepressants. In his landmark 1995 paper, he discovered that antidepressants increase the gene expression of Brain-Derived Neurotrophic Factor, or (BDNF)[2] in the hippocampus. In a later paper he discovered that the downstream effect of BDNF is to increase neurogenesis or the formation of new neurons in the dentate gyrus of the hippocampus.[3]

The results of this work led him to formulate the hypothesis that depression is caused by a decrease in hippocampal neurogenesis caused by elevated cortisol levels.