SPIB

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Spi-B transcription factor (Spi-1/PU.1 related)
Identifiers
Symbols SPIB ; SPI-B
External IDs OMIM606802 MGI892986 HomoloGene79220 GeneCards: SPIB Gene
RNA expression pattern
PBB GE SPIB 205861 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6689 272382
Ensembl ENSG00000142539 ENSMUSG00000008193
UniProt Q01892 O35906
RefSeq (mRNA) NM_001243998 NM_019866
RefSeq (protein) NP_001230927 NP_063919
Location (UCSC) Chr 19:
50.92 – 50.93 Mb
Chr 7:
44.53 – 44.53 Mb
PubMed search [1] [2]

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.12

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM]2

Interactions

SPIB has been shown to interact with MAPK33 and MAPK8.3

References

  1. ^ Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Mol Cell Biol 12 (10): 4297–304. PMC 360353. PMID 1406622. 
  2. ^ a b "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)". 
  3. ^ a b Mao, C; Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene (ENGLAND) 12 (4): 863–73. ISSN 0950-9232. PMID 8632909. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.