Serotonin receptor agonist
Serotonin receptor agonist - Wikipedia, the free encyclopedia
Serotonin receptor agonist
From Wikipedia, the free encyclopedia
A serotonin receptor agonist is a compound that activates serotonin receptors , in a manner similar to serotonin .
Non-selective agonists Psilocin and DMT are serotonin analogs found in certain plants or mushrooms. These compounds act on a variety of serotonin receptor types.
5-HT1A agonists Azapirones such as buspirone , gepirone , and tandospirone are 5-HT1A agonists marketed primarily as anxiolytics , but also recently as antidepressants .
5-HT1B agonists Triptans such as sumatriptan , rizatriptan , and naratriptan , are 5-HT1B receptor agonists that are used to abort migraine and cluster headache attacks.
5-HT1D agonists In addition to being 5-HT1B agonists, triptans are also agonists at the 5-HT1D receptor, which contributes to their antimigraine effect caused by vasoconstriction of blood vessels in the brain.
5-HT1F agonists LY-334,370 was a selective 5-HT1F agonist that was being developed by Eli Lilly and Company for the treatment of migraine and cluster headaches. Development was halted however due to toxicity detected in animal test subjects. Lasmiditan has successfully completed Phase II clinical trials in early 2010.
5-HT2A agonists Psychedelic drugs like LSD , mescaline , and 2C-B , act as 5-HT2A agonists. Their action at this receptor is responsible for their "psychedelic" effects. Some of these drugs, act as agonists for other 5HT receptor subtypes. Not all 5-HT2A agonists are psychoactive.
5-HT2C agonists Lorcaserin is a thermogenic and anorectic weight-loss drug which acts as a selective 5-HT2C agonist.
5-HT4 agonists Cisapride and Tegaserod are 5-HT4 partial receptor agonist that were used to treat disorders of gastrointestinal motility. Prucalopride is a highly selective 5-HT4 receptor agonist that can be used to treat certain disorders of gastrointestinal motility. Other 5-HT4 agonists have shown potential to be nootropic type drugs via promoting acetylcholine release.
5-HT7 agonists AS-19 (drug) is a 5-HT7 receptor agonist that has been used only in research.
See also
References
^ Aghajanian, M.D., G.K.; G.J. Marek, M.D., Ph.D. (1999). "Serotonin and Hallucinogens". Neuropharmacology 21 (No. 2S): 16S.
External links
Agonists : Azapirones : Alnespirone Binospirone Buspirone Enilospirone Eptapirone Gepirone Ipsapirone Perospirone Revospirone Tandospirone Tiospirone Umespirone Zalospirone ; Antidepressants : Etoperidone Nefazodone Trazodone Vortioxetine ; Antipsychotics : Aripiprazole Asenapine Clozapine Quetiapine Ziprasidone ; Ergolines : Dihydroergotamine Bromocriptine Ergotamine Lisuride Methysergide LSD ; Tryptamines : 5-CT 5-MeO-DMT 5-MT Bufotenin DMT Indorenate Psilocin Psilocybin ; Others : 8-OH-DPAT Adatanserin Bay R 1531 Befiradol BMY-14802 Cannabidiol Dimemebfe Ebalzotan Eltoprazine F-11,461 F-12,826 F-13,714 F-14,679 F-15,063 F-15,599 Flesinoxan Flibanserin Lesopitron LY-293,284 LY-301,317 MKC-242 Naluzotan NBUMP Osemozotan Oxaflozane Pardoprunox Piclozotan Rauwolscine Repinotan Roxindole RU-24,969 S 14,506 S-14,671 S-15,535 Sarizotan SSR-181,507 Sunepitron U-92,016-A Urapidil Vilazodone Xaliproden Yohimbine Antagonists : Antipsychotics : Iloperidone Risperidone Sertindole ; Beta blockers : Alprenolol Cyanopindolol Iodocyanopindolol Oxprenolol Pindobind Pindolol Propranolol Tertatolol ; Others : AV965 BMY-7,378 CSP-2503 Dotarizine Flopropione GR-46611 Isamoltane Lecozotan Mefway Metitepine/Methiothepin MPPF NAN-190 Robalzotan S-15535 SB-649,915 SDZ 216-525 Spiperone Spiramide Spiroxatrine UH-301 WAY-100,135 WAY-100,635 Xylamidine
Agonists : Lysergamides : Dihydroergotamine Methysergide ; Triptans : Almotriptan Avitriptan Eletriptan Frovatriptan Naratriptan Rizatriptan Sumatriptan Zolmitriptan ; Tryptamines : 5-CT 5-Ethyl-DMT 5-MT 5-(Nonyloxy)tryptamine ; Others : CP-135,807 Bromocriptine CP-286,601 GR-46611 L-694,247 L-772,405 PNU-109,291 PNU-142633 Antagonists : Lysergamides : Metergoline ; Others : Alniditan BRL-15,572 Elzasonan GR-127,935 Ketanserin LY-310,762 LY-367,642 LY-456,219 LY-456,220 Metitepine/Methiothepin Ritanserin Yohimbine Ziprasidone
Agonists : Phenethylamines : 2C-B 2C-E 2C-I 2C-T-2 2C-T-7 2C-T-21 DOB DOC DOI DOM MDA MDMA Mescaline ; Piperazines : Aripiprazole mCPP TFMPP ; Tryptamines : 5-CT 5-MeO-α-ET 5-MeO-α-MT 5-MeO-DET 5-MeO-DiPT 5-MeO-DMT 5-MeO-DPT 5-MT α-ET α-Methyl-5-HT α-MT Bufotenin DET DiPT DMT DPT Psilocin Psilocybin ; Others : A-372,159 Bromocriptine AL-38022A CP-809,101 Dimemebfe Lorcaserin Medifoxamine MK-212 Org 12,962 ORG-37,684 Oxaflozane PNU-22394 Ro60-0175 Ro60-0213 Vabicaserin WAY-629 WAY-161,503 YM-348 Antagonists : Atypical antipsychotics : Clorotepine Clozapine Iloperidone Melperone Olanzapine Paliperidone Pimozide Quetiapine Risperidone Sertindole Ziprasidone Zotepine ; Typical antipsychotics : Chlorpromazine Loxapine Pipamperone ; Antidepressants : Agomelatine Amitriptyline Amoxapine Aptazapine Etoperidone Fluoxetine Mianserin Mirtazapine Nefazodone Nortriptyline Tedatioxetine Trazodone ; Others : Adatanserin CEPC Cinanserin Cyproheptadine Deramciclane Dotarizine Eltoprazine Esmirtazapine FR-260,010 Ketanserin Ketotifen Latrepirdine Metitepine/Methiothepin Methysergide Pizotifen Ritanserin RS-102,221 S-14,671 SB-200,646 SB-206,553 SB-221,284 SB-228,357 SB-242,084 SB-243,213 SDZ SER-082 Xylamidine
Agonists : Lysergamides : Dihydroergotamine Ergotamine Lisuride LSD Mesulergine Metergoline Methysergide ; Tryptamines : 2-Methyl-5-HT 5-BT 5-CT 5-MT Bufotenin E-6801 E-6837 EMD-386,088 EMDT LY-586,713 N -Methyl-5-HTTryptamine ; Others : WAY-181,187 WAY-208,466 Antagonists : Antidepressants : Amitriptyline Amoxapine Clomipramine Doxepin Mianserin Nortriptyline ; Atypical antipsychotics : Aripiprazole Asenapine Clorotepine Clozapine Fluperlapine Iloperidone Olanzapine Tiospirone ; Typical antipsychotics : Chlorpromazine Loxapine ; Others : BGC20-760 BVT-5182 BVT-74316 Cerlapirdine EGIS-12,233 GW-742,457 Ketanserin Latrepirdine Lu AE58054 Metitepine/Methiothepin MS-245 PRX-07034 Ritanserin Ro04-6790 Ro 63-0563 SB-258,585 SB-271,046 SB-357,134 SB-399,885 SB-742,457
Agonists : Lysergamides : LSD ; Tryptamines : 5-CT 5-MT Bufotenin ; Others : 8-OH-DPAT AS-19 Bifeprunox E-55888 LP-12 LP-44 RU-24,969 Sarizotan Antagonists : Lysergamides : 2-Bromo-LSD Bromocriptine Dihydroergotamine Ergotamine Mesulergine Metergoline Methysergide ; Antidepressants : Amitriptyline Amoxapine Clomipramine Imipramine Maprotiline Mianserin ; Atypical antipsychotics : Amisulpride Aripiprazole Clorotepine Clozapine Olanzapine Risperidone Sertindole Tiospirone Ziprasidone Zotepine ; Typical antipsychotics : Chlorpromazine Loxapine ; Others : Butaclamol EGIS-12,233 Ketanserin LY-215,840 Metitepine/Methiothepin Pimozide Ritanserin SB-258,719 SB-258,741 SB-269,970 SB-656,104 SB-656,104-A SB-691,673 SLV-313 SLV-314 Spiperone SSR-181,507 Vortioxetine
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