1. Human urinary system: 2. Kidney, 3. Renal pelvis, 4. Ureter, 5. Urinary bladder, 6. Urethra. (Left side with frontal section)
Kidneys → Ureters → Urinary Bladder → Urethra
The urinary system, also known as the renal system, consists of the two kidneys, ureters, the bladder, and the urethra. Each kidney consists of millions of functional units called nephrons. The purpose of the renal system is to eliminate wastes from the body, regulate blood volume and pressure, control levels of electrolytes and metabolites, and regulate blood pH. The kidneys have extensive blood supply via the renal arteries which leave the kidneys via the renal vein. Following filtration of blood and further processing, wastes (in the form of urine) exit the kidney via the ureters, tubes made of smooth muscle fibers that propel urine towards the urinary bladder, where it is stored and subsequently expelled from the body by urination (voiding). The female and male urinary system are very similar, differing only in the length of the urethra.1
Urine is formed in the kidneys through a filtration of blood. The urine is then passed through the ureters to the bladder, where it is stored. During urination (peeing) the urine is passed from the bladder through the urethra to the outside of the body.
About 1-2 litres of urine are produced every day in a healthy human, although this amount may vary according to circumstances such as fluid intake.
There are several functions of the Urinary System:
- Removal of waste product from the body (mainly urea and uric acid)
- Regulation of electrolyte balance (e.g. sodium, potassium and calcium)
- Regulation of acid-base homeostasis
- Controlling blood volume and maintaining blood pressure
Average urine production in adult humans is about 1 – 2 L per day, depending on state of hydration, activity level, environmental factors, weight, and the individual's health. Producing too much or too little urine needs medical attention. Polyuria is a condition of excessive production of urine (> 2.5 L/day), oliguria when < 400 mL are produced, and anuria one of < 100 mL per day.
The first step in urine formation is the filtration of blood in the kidneys. In a healthy human the kidney receives between 12 and 30% of cardiac output, but it averages about 20% or about 1.25 L/min.
The basic structural and functional unit of the kidney is the nephron. Its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine.
In the first part of the nephron, the renal corpuscle blood is being filtrated from the circulatory system into the nephron. A pressure difference between forces the filtrate from the blood across the filtration membrane. The filtrate includes water, small molecules and ions that easily pass through the filtration membrane. However larger molecules such as proteins and blood cells are prevented from passing through the filtration membrane. The amount of filtrate produced every minute is called the glomerular filtration rate or GFR and amounts to a staggering 180 litres per day. About 99% of this filtrate is then reabsorbed as it passes through the nephron and the remaining 1% becomes urine.
Antidiuretic hormone (ADH), is a neurohypophysial hormone found in most mammals. Its two primary functions are to retain water in the body and to constrict blood vessels. Vasopressin regulates the body's retention of water by acting to increase water absorption in the collecting ducts of the kidney nephron.3 Vasopressin increases water permeability of the kidney's collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the kidney nephron collecting duct plasma membrane.4
Urine moves from the nephrones collecting duct system to the minor calyx and then the major calyx before entering the renal pelvis, a funnel-like dilated proximal part of the ureter within the kidney. The major function of the renal pelvis is to act as a funnel for urine flowing to the ureter. From here the urine flows through the ureters to the bladder, where it is stored until urination takes place.
Urination is the ejection of urine from the urinary bladder through the urethra to the outside of the body. In healthy humans (and many other animals), the process of urination is under voluntary control. In infants, some elderly individuals, and those with neurological injury, urination may occur as an involuntary reflex. In other animals, in addition to expelling waste material, urination can mark territory or express submissiveness. Physiologically, micturition involves coordination between the central, autonomic, and somatic nervous systems. Brain centers that regulate urination include the pontine micturition center, periaqueductal gray, and the cerebral cortex. In male placental mammals, urine is ejected through the penis, and in female placental mammals through the vulva.
Urologic disease can involve congenital or acquired dysfunction of the urinary system.
Kidney diseases are normally investigated and treated by nephrologists, while the specialty of urology deals with problems in the other organs. Gynecologists may deal with problems of incontinence in women.
Diseases of other bodily systems also have a direct effect on urogenital function. For instance it has been shown that protein released by the kidneys in diabetes mellitus sensitises the kidney to the damaging effects of hypertension.5
- C. Dugdale, David (16 September 2011). "Female urinary tract". MedLine Plus Medical Encyclopedia.
- Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart, Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1.
- Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications". In Lajtha A, Lim R. Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (3rd ed.). Berlin: Springer. pp. 573–607. ISBN 0-387-30348-0.
- Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA (February 1995). "Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1013–7. doi:10.1073/pnas.92.4.1013. PMC 42627. PMID 7532304.
- Baba, T; Murabayashi, S; Tomiyama, T; Takebe, K (1990). "Uncontrolled hypertension is associated with a rapid progression of nephropathy in type 2 diabetic patients with proteinuria and preserved renal function". The Tohoku journal of experimental medicine 161 (4): 311–8. doi:10.1620/tjem.161.311. PMID 2256104.
- "Peripheral Neuropathy". Patient UK. Retrieved 20/03/2014.
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