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YY1 transcription factor
Protein YY1 PDB 1ubd.png
PDB rendering based on 1ubd.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600013 MGI99150 HomoloGene2556 GeneCards: YY1 Gene
RNA expression pattern
PBB GE YY1 201901 s at tn.png
PBB GE YY1 201902 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7528 22632
Ensembl ENSG00000100811 ENSMUSG00000021264
UniProt P25490 Q00899
RefSeq (mRNA) NM_003403 NM_009537
RefSeq (protein) NP_003394 NP_033563
Location (UCSC) Chr 14:
100.24 – 100.28 Mb
Chr 12:
108.79 – 108.82 Mb
PubMed search [1] [2]

YY1 (Yin Yang 1)1 is a transcriptional repressor protein in humans that is encoded by the YY1 gene.23

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.4


YY1 has been shown to interact with Histone deacetylase 2,567 FKBP3,8 ATF6,9 Myc,10 SAP30,11 EP300,612 HDAC3,56 NOTCH113 and RYBP.14


  1. ^ Thiaville, MM; Kim, J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes.". Critical reviews in oncogenesis 16 (3-4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMID 22248054. 
  2. ^ Shi Y, Seto E, Chang LS, Shenk T (November 1991). "Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein". Cell 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. 
  3. ^ Zhu W, Lossie AC, Camper SA, Gumucio DL (July 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mamm Genome 5 (4): 234–6. doi:10.1007/BF00360552. PMID 7912122. 
  4. ^ "Entrez Gene: YY1 YY1 transcription factor". 
  5. ^ a b Yang, W M; Yao Y L; Sun J M; Davie J R; Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. (UNITED STATES) 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. ISSN 0021-9258. PMID 9346952. 
  6. ^ a b c Yao, Y L; Yang W M; Seto E (September 2001). "Regulation of Transcription Factor YY1 by Acetylation and Deacetylation". Mol. Cell. Biol. (United States) 21 (17): 5979–91. doi:10.1128/MCB.21.17.5979-5991.2001. ISSN 0270-7306. PMC 87316. PMID 11486036. 
  7. ^ Kalenik, J L; Chen D; Bradley M E; Chen S J; Lee T C (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. (ENGLAND) 25 (4): 843–9. doi:10.1093/nar/25.4.843. ISSN 0305-1048. PMC 146511. PMID 9016636. 
  8. ^ Yang, W M; Yao Y L; Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. (England) 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. ISSN 0261-4189. PMC 125595. PMID 11532945. 
  9. ^ Li, M; Baumeister P; Roy B; Phan T; Foti D; Luo S; Lee A S (July 2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. ISSN 0270-7306. PMC 85959. PMID 10866666. 
  10. ^ Shrivastava, A; Saleque S; Kalpana G V; Artandi S; Goff S P; Calame K (Dec 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science (UNITED STATES) 262 (5141): 1889–92. doi:10.1126/science.8266081. ISSN 0036-8075. PMID 8266081. 
  11. ^ Huang, Nu En; Lin Ching Hui; Lin Young Sun; Yu Winston C Y (June 2003). "Modulation of YY1 activity by SAP30". Biochem. Biophys. Res. Commun. (United States) 306 (1): 267–75. doi:10.1016/S0006-291X(03)00966-5. ISSN 0006-291X. PMID 12788099. 
  12. ^ Lee, J S; Galvin K M; See R H; Eckner R; Livingston D; Moran E; Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. (UNITED STATES) 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. ISSN 0890-9369. PMID 7758944. 
  13. ^ Yeh, Tien-Shun; Lin Yu-Min; Hsieh Rong-Hong; Tseng Min-Jen (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". J. Biol. Chem. (United States) 278 (43): 41963–9. doi:10.1074/jbc.M304353200. ISSN 0021-9258. PMID 12913000. 
  14. ^ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680. 

Further reading

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