YY1

YY1 transcription factor
	; PDB rendering based on 1ubd.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1UBD, 1ZNM
Identifiers
Symbols	YY1; DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1
External IDs	OMIM: 600013 MGI: 99150 HomoloGene: 2556 GeneCards: YY1 Gene
Gene Ontology
Molecular function	• four-way junction DNA binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; • DNA binding; • sequence-specific DNA binding transcription factor activity; • transcription coactivator activity; • transcription corepressor activity; • RNA binding; • protein binding; • zinc ion binding; • transcription regulatory region DNA binding;
Cellular component	• nucleus; • transcription factor complex; • plasma membrane; • nuclear matrix; • Ino80 complex; • PcG protein complex;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • double-strand break repair via homologous recombination; • regulation of transcription from RNA polymerase II promoter; • RNA localization; • response to DNA damage stimulus; • spermatogenesis; • anterior/posterior pattern specification; • response to UV-C; • cell differentiation; • cellular response to UV; • response to prostaglandin F stimulus; • camera-type eye morphogenesis; • chromosome organization;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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Transcriptional repressor protein YY1 is a protein that in humans is encoded by the YY1 gene.¹²

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name standing for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.³

Interactions

YY1 has been shown to interact with Histone deacetylase 2,⁴⁵⁶ FKBP3,⁷ ATF6,⁸ Myc,⁹ SAP30,¹⁰ EP300,⁵¹¹ HDAC3,⁴⁵ NOTCH1¹² and RYBP.¹³

References

^ Shi Y, Seto E, Chang LS, Shenk T (November 1991). "Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein". Cell 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281.
^ Zhu W, Lossie AC, Camper SA, Gumucio DL (July 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mamm Genome 5 (4): 234–6. doi:10.1007/BF00360552. PMID 7912122.
^ "Entrez Gene: YY1 YY1 transcription factor".
^ ^a ^b Yang, W M; Yao Y L, Sun J M, Davie J R, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. (UNITED STATES) 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. ISSN 0021-9258. PMID 9346952.
^ ^a ^b ^c Yao, Y L; Yang W M, Seto E (September 2001). "Regulation of Transcription Factor YY1 by Acetylation and Deacetylation". Mol. Cell. Biol. (United States) 21 (17): 5979–91. doi:10.1128/MCB.21.17.5979-5991.2001. ISSN 0270-7306. PMC 87316. PMID 11486036.
^ Kalenik, J L; Chen D, Bradley M E, Chen S J, Lee T C (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. (ENGLAND) 25 (4): 843–9. doi:10.1093/nar/25.4.843. ISSN 0305-1048. PMC 146511. PMID 9016636.
^ Yang, W M; Yao Y L, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. (England) 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. ISSN 0261-4189. PMC 125595. PMID 11532945.
^ Li, M; Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee A S (July 2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. ISSN 0270-7306. PMC 85959. PMID 10866666.
^ Shrivastava, A; Saleque S, Kalpana G V, Artandi S, Goff S P, Calame K (Dec. 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science (UNITED STATES) 262 (5141): 1889–92. doi:10.1126/science.8266081. ISSN 0036-8075. PMID 8266081.
^ Huang, Nu En; Lin Ching Hui, Lin Young Sun, Yu Winston C Y (June 2003). "Modulation of YY1 activity by SAP30". Biochem. Biophys. Res. Commun. (United States) 306 (1): 267–75. doi:10.1016/S0006-291X(03)00966-5. ISSN 0006-291X. PMID 12788099.
^ Lee, J S; Galvin K M, See R H, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. (UNITED STATES) 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. ISSN 0890-9369. PMID 7758944.
^ Yeh, Tien-Shun; Lin Yu-Min, Hsieh Rong-Hong, Tseng Min-Jen (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". J. Biol. Chem. (United States) 278 (43): 41963–9. doi:10.1074/jbc.M304353200. ISSN 0021-9258. PMID 12913000.
^ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680.

External links

FactorBook YY1

[pmid1655281-1] Shi Y, Seto E, Chang LS, Shenk T (November 1991). "Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein". Cell 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281.

[pmid7912122-2] Zhu W, Lossie AC, Camper SA, Gumucio DL (July 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mamm Genome 5 (4): 234–6. doi:10.1007/BF00360552. PMID 7912122.

[3] "Entrez Gene: YY1 YY1 transcription factor".

[pmid9346952-4] Yang, W M; Yao Y L, Sun J M, Davie J R, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. (UNITED STATES) 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. ISSN 0021-9258. PMID 9346952.

[pmid11486036-5] Yao, Y L; Yang W M, Seto E (September 2001). "Regulation of Transcription Factor YY1 by Acetylation and Deacetylation". Mol. Cell. Biol. (United States) 21 (17): 5979–91. doi:10.1128/MCB.21.17.5979-5991.2001. ISSN 0270-7306. PMC 87316. PMID 11486036.

[pmid9016636-6] Kalenik, J L; Chen D, Bradley M E, Chen S J, Lee T C (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. (ENGLAND) 25 (4): 843–9. doi:10.1093/nar/25.4.843. ISSN 0305-1048. PMC 146511. PMID 9016636.

[pmid11532945-7] Yang, W M; Yao Y L, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. (England) 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. ISSN 0261-4189. PMC 125595. PMID 11532945.

[pmid10866666-8] Li, M; Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee A S (July 2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. ISSN 0270-7306. PMC 85959. PMID 10866666.

[pmid8266081-9] Shrivastava, A; Saleque S, Kalpana G V, Artandi S, Goff S P, Calame K (Dec. 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science (UNITED STATES) 262 (5141): 1889–92. doi:10.1126/science.8266081. ISSN 0036-8075. PMID 8266081.

[pmid12788099-10] Huang, Nu En; Lin Ching Hui, Lin Young Sun, Yu Winston C Y (June 2003). "Modulation of YY1 activity by SAP30". Biochem. Biophys. Res. Commun. (United States) 306 (1): 267–75. doi:10.1016/S0006-291X(03)00966-5. ISSN 0006-291X. PMID 12788099.

[pmid7758944-11] Lee, J S; Galvin K M, See R H, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. (UNITED STATES) 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. ISSN 0890-9369. PMID 7758944.

[pmid12913000-12] Yeh, Tien-Shun; Lin Yu-Min, Hsieh Rong-Hong, Tseng Min-Jen (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". J. Biol. Chem. (United States) 278 (43): 41963–9. doi:10.1074/jbc.M304353200. ISSN 0021-9258. PMID 12913000.

[pmid10369680-13] García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680.

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YY1

Contents

Interactions

References

Further reading

External links