ZEB1

Zinc finger E-box binding homeobox 1
	; PDB rendering of ZEB1's homeodomain based on 2e19.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2E19
Identifiers
Symbols	ZEB1; AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A
External IDs	OMIM: 189909 MGI: 1344313 HomoloGene: 31779 GeneCards: ZEB1 Gene
Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity; • transcription coactivator activity; • transcription corepressor activity; • protein binding; • zinc ion binding; • sequence-specific DNA binding; • E-box binding;
Cellular component	• nucleus; • nucleolus; • cytoplasm;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • transcription, DNA-dependent; • regulation of transcription from RNA polymerase II promoter; • immune response; • cell proliferation; • positive regulation of neuron differentiation; • negative regulation of transcription, DNA-dependent;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; ;

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.¹²³

TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.³⁴

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3.

References

^ Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (Dec 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ 3rd, Kant JA (Feb 1992). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
^ ^a ^b "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.

Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.". Mol. Cell. Biol. 14 (10): 6773–88. PMC 359208. PMID 7935395.
Watanabe Y, Kawakami K, Hirayama Y, Nagano K (1994). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene.". J. Biochem. 114 (6): 849–55. PMID 8138542.
Ikeda K, Halle JP, Stelzer G, et al. (1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.". Mol. Cell. Biol. 18 (1): 10–8. PMC 121442. PMID 9418848.
Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8. doi:10.1073/pnas.96.12.6683. PMC 21975. PMID 10359772.
Hlubek F, Löhberg C, Meiler J, et al. (2001). "Tip60 is a cell-type-specific transcriptional regulator.". J. Biochem. 129 (4): 635–41. PMID 11275565.
Locklin RM, Riggs BL, Hicok KC, et al. (2002). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology.". J. Bone Miner. Res. 16 (12): 2192–204. doi:10.1359/jbmr.2001.16.12.2192. PMID 11760832.
Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles.". J. Biomed. Sci. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028.
Guaita S, Puig I, Franci C, et al. (2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.". J. Biol. Chem. 277 (42): 39209–16. doi:10.1074/jbc.M206400200. PMID 12161443.
Costantino ME, Stearman RP, Smith GE, Darling DS (2002). "Cell-specific phosphorylation of Zfhep transcription factor.". Biochem. Biophys. Res. Commun. 296 (2): 368–73. doi:10.1016/S0006-291X(02)00880-X. PMID 12163027.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Postigo AA (2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.". EMBO J. 22 (10): 2443–52. doi:10.1093/emboj/cdg225. PMC 155983. PMID 12743038.
Postigo AA, Depp JL, Taylor JJ, Kroll KL (2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.". EMBO J. 22 (10): 2453–62. doi:10.1093/emboj/cdg226. PMC 155984. PMID 12743039.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dillner NB, Sanders MM (2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades.". DNA Cell Biol. 23 (1): 25–34. doi:10.1089/104454904322745907. PMID 14965470.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Shimizu S, Krafchak C, Fuse N, et al. (2005). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10.". Am. J. Med. Genet. A 130 (4): 372–7. doi:10.1002/ajmg.a.30267. PMC 1249494. PMID 15384081.
Eger A, Aigner K, Sonderegger S, et al. (2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.". Oncogene 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.

External links

FactorBook ZEB1

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[pmid1427828-1] Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (Dec 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.

[pmid1840704-2] Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ 3rd, Kant JA (Feb 1992). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.

[entrez-3] "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".

[autogenerated1-4] Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.

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ZEB1

Contents

Clinical significance

References

Further reading

External links